I am using a eGPU with my 15" MBPr but only for Windows, because there are still problems in managing the display output in OSX. But you can make a eGPU run any rendering software if you get the implementation in OSX right.
This is my system (GTX 970 in an AKiTiO Thunder2 case)...
I used a Seasonix X-560 to strip apart. Had to do some soldering to extend some wires:
http://www.tonymacx86.com/powermac-g5/96689-dschijns-2nd-g5-mod-dust-free.html
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